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HS-10383ÊǺ²É­ÖÆÒ©×ÔÖ÷Ñз¢µÄÒ»ÖÖ¸ßÑ¡ÔñÐÔµÄP2X3ÊÜÌåÞ׿¹¼Á£¬£¬£¬£¬£¬£¬¿ª·¢ÓÃÓÚÖÎÁÆRUCC¡£¡£¡£¡£¡£P2X3ÊÜÌåÔÚ¿ÈËÔ´«µ¼Í¨Â·ÖÐÊÎÑÝÖ÷Òª½ÇÉ«£¬£¬£¬£¬£¬£¬±»ÒÔΪÊÇÖÎÁÆRUCCµÄÖ÷Òª°Ðµã¡£¡£¡£¡£¡£¶àÏîÁÙ´²ÊÔÑéÒÑ·¢Ã÷P2X3ÊÜÌåÞ׿¹¼Á×÷ΪDZÔÚÁÆ·¨£¬£¬£¬£¬£¬£¬¿ÉΪRUCC»¼Õß´øÀ´ÐµÄÖÎÁÆÏ£Íû¡£¡£¡£¡£¡£¹«Ë¾ÒÔΪÆä¸ßÑ¡ÔñÐÔµÄP2X3Þ׿¹¼Á¾ßÓÐÆæÒìÓÅÊÆ£¬£¬£¬£¬£¬£¬±»ÒÔΪÊÇÖÎÁÆRUCCµÄÓÐÓÃ;¾¶£¬£¬£¬£¬£¬£¬ÄÜÓÐÓýµµÍ¿ÈËÔƵÂʶø¶Ôζ¾õ¹¦Ð§½ÏС£¡£¡£¡£¡£¬£¬£¬£¬£¬£¬´Ó¶ø¿ÉÒÔΪ»¼Õß´øÀ´½ÏºÃµÄÁÆЧºÍÖÎÁÆÒÀ´ÓÐÔ¡£¡£¡£¡£¡£

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1. Li, Q., Chen, K., Zhang, Y., Zhou, H., Ye, P., Song, L., Zhao, F., Shi, J., Wu, Q., Zhang, J., Jia, W., Kong, K., Tao, Y., Yang, X., & Zhao, W. (2024). Safety, tolerability, and pharmacokinetics of HS-10383 in healthy subjects: A randomized, double-blind, placebo-controlled, and multiple dose-ascending phase I trial. Abstract presented at the 2024 Congress of the Asian Pacific Society of Respirology (APSR), Hong Kong, China. Abstract 1302.

2. Gao, Z., Xu, Y., Zhang, X., Yang, J., Wang, Z., & Jiang, S. (2019). Prevalence and characteristics of chronic cough in the general population in Guangzhou, southern China. Respiratory Medicine, 155, 43-48.

3. Xu, Y., Zhang, X., Lin, J., & Chen, Q. (2018). Clinical characteristics and potential predictors for chronic cough in Chinese patients. Journal of Thoracic Disease, 10(1), 123-130. 

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